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Description

PE131010: β-GalNAc-PEG3-AlkyneC17H29NO9 391. 41 A D N acetylgalactosamine (GalNAc) ligand equipped with a terminal alkyne through a hydrophilic PEG3 spacer. The alkyne couples to azide functionalized partners via copper catalyzed azide alkyne cycloaddition (CuAAC), forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR), which is highly expressed on

46 / A β-D-N-acetyllactosamine (LacNAc) ligand equipped with a terminal carboxylic acid through a short butyl spacer

immunogenicity

the probe is also suited to metabolic glycoengineering and cell-based studies where membrane permeability is required prior to intracellular deprotection

Fmoc-Ser([Galβ(1-4)Glc](Ac)7)-OH

C45H54N4O20 / 970

aa length 10) with Sialyl TF (Neu5Acα2-3Galβ1-3GalNAc) at Thr541

/ α-GalNAc-PEG3-Acid / α-GalNAc-PEG3-COOH

2-{2-[2-(Prop-2-ynyloxy)ethoxy]ethoxy}ethyl β-D-lactopyranoside

/ MUC1(126-149)-STn(144) / Mucin1

6-O-triacetyl-2-deoxy-β-D-galactopyranoside

/ β-D-Lac-Butyl-Carboxylic Acid / β-Lac-Bu-CO2H

T Antigen (Serine)

Exchange/Return Notes