AG931000: GlcNAcβ(1-4)GlcNAc-β-Propyl-PEG4-DBCO

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Description

AG931000: GlcNAcβ(1-4)GlcNAc-β-Propyl-PEG4-DBCOC49H70N6O17 1015. 1 A chitobiose (GlcNAc1 4GlcNAc) ligand equipped with a dibenzocyclooctyne (DBCO) handle through a propyl PEG4 spacer. The DBCO group reacts with azide functionalized partners via copper free strain promoted azide alkyne cycloaddition (SPAAC), forming stable 1,2,3 triazole linkages without a copper catalyst. This compound provides a chitobiose (GlcNAc1 4GlcNAc) building block, the core disaccharide of N linked glycans, useful for

68 / / 25-Hydroxy Vitamin D3-d6 / Calcidiol-d6

β-D-GalNAc with 5-aminohexyl linker/spacer

N-Cbz-6-aminohexyl

/ β-D-Gal-Ethyl-Azide / β-Gal-Et-N3

45 / A fully unprotected (free amine

The trivalent presentation of GalNAcβ residues engages multiple carbohydrate-recognition domains of ASGPR simultaneously

β-D-GalNAc with Boc-5-aminopentyl linker/spacer

α-D-Man-Butyl-Carboxylic Acid

/ Fmoc-Thr(Neu5Acα(2-6)GalNAc)-OH (Peracetate

C8H15N3O5 / 233

1α-Hydroxyergocalciferol-d6

free acid)